Study of platelet-associated immunoglobulins of IgG, IgM, IgA, and IgE classes and platelet kinetics in 33 patients with idiopathic thrombocytopenic purpura
Identifieur interne : 000148 ( Main/Exploration ); précédent : 000147; suivant : 000149Study of platelet-associated immunoglobulins of IgG, IgM, IgA, and IgE classes and platelet kinetics in 33 patients with idiopathic thrombocytopenic purpura
Auteurs : RBID : ISTEX:277_1994_Article_BF01695692.pdfEnglish descriptors
Abstract
The role of platelet-associated immunoglobulins (PAIg) of four different immunoglobulin classes -IgM, IgG, IgA, and IgE- and their relation to platelet count and platelet kinetics was studied in 33 patients with idiopathic thrombocytopenic purpura (ITP). During the course of 1 year, repeated determinations of PAIg were made. The results indicate that PAIgG, PAIgM, and PAIgA are present in all ITP patients, and that autoantibodies of all three Ig classes show highly significant correlations to the platelet counts (p< 0.0001). Double logarithmic negative correlations have been found between PAIgG and platelet count (r=−0.71), PAIgM and platelet count (r=−0.84), and PAIgA and platelet count (r=−0.79). Statistical analyses using partial correlation and multiple regression methods showed that PAIgM is predominantly related to the platelet count, whereas PAIgG and PAIgA are only of secondary importance. Accordingly, a relation of PAIgM (and PAIgA) to increased liver destruction of platelets was found in kinetic studies using111indium-labeled platelets. Taken together, these results suggest a predominant role of PAIgM in the pathogenesis of ITP.
DOI: 10.1007/BF01695692
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Le Blanc</name><affiliation wicri:level="3"><mods:affiliation>Division of Hematology and Oncology, Medical School of Hannover, Hannover, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Hematology and Oncology, Medical School of Hannover, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name>O. Schober</name><affiliation wicri:level="3"><mods:affiliation>Division of Nuclear Medicine, Medical School of Hannover, Hannover, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Nuclear Medicine, Medical School of Hannover, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name>R. Coldewey</name><affiliation wicri:level="3"><mods:affiliation>Division of Immunology, Medical School of Hannover, Hannover, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Immunology, Medical School of Hannover, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name>H. Deicher</name><affiliation wicri:level="3"><mods:affiliation>Division of Immunology, Medical School of Hannover, Hannover, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Immunology, Medical School of Hannover, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="RBID">ISTEX:277_1994_Article_BF01695692.pdf</idno><date when="1994">1994</date><idno type="doi">10.1007/BF01695692</idno><idno type="wicri:Area/Main/Corpus">000027</idno><idno type="wicri:Area/Main/Curation">000027</idno><idno type="wicri:Area/Main/Exploration">000148</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Autoimmunity</term><term>ITP</term><term>Platelet-associated immunoglobulins</term><term>Purpura</term><term>Thrombocytopenic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">The role of platelet-associated immunoglobulins (PAIg) of four different immunoglobulin classes -IgM, IgG, IgA, and IgE- and their relation to platelet count and platelet kinetics was studied in 33 patients with idiopathic thrombocytopenic purpura (ITP). During the course of 1 year, repeated determinations of PAIg were made. The results indicate that PAIgG, PAIgM, and PAIgA are present in all ITP patients, and that autoantibodies of all three Ig classes show highly significant correlations to the platelet counts (p< 0.0001). Double logarithmic negative correlations have been found between PAIgG and platelet count (r=−0.71), PAIgM and platelet count (r=−0.84), and PAIgA and platelet count (r=−0.79). Statistical analyses using partial correlation and multiple regression methods showed that PAIgM is predominantly related to the platelet count, whereas PAIgG and PAIgA are only of secondary importance. Accordingly, a relation of PAIgM (and PAIgA) to increased liver destruction of platelets was found in kinetic studies using111indium-labeled platelets. Taken together, these results suggest a predominant role of PAIgM in the pathogenesis of ITP.</div></front></TEI><mods xsi:schemaLocation="http://www.loc.gov/mods/v3 file:///applis/istex/home/loadistex/home/etc/xsd/mods.xsd" version="3.4" istexId="045511eecc988a90e4756b372fdc75ddccfaa274"><titleInfo lang="eng"><title>Study of platelet-associated immunoglobulins of IgG, IgM, IgA, and IgE classes and platelet kinetics in 33 patients with idiopathic thrombocytopenic purpura</title></titleInfo><name type="personal"><namePart type="given">M. R. Movahed Shariat</namePart><namePart type="family">Panahi</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Medicine, Strong Memorial Hospital, University of Rochester Medical Center, 601 Elmwood Avenue, P.O. Box 702, 14642, Rochester, NY, USA</affiliation></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Le Blanc</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Division of Hematology and Oncology, Medical School of Hannover, Hannover, Germany</affiliation></name><name type="personal"><namePart type="given">O.</namePart><namePart type="family">Schober</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Division of Nuclear Medicine, Medical School of Hannover, Hannover, Germany</affiliation></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Coldewey</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Division of Immunology, Medical School of Hannover, Hannover, Germany</affiliation></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Deicher</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Division of Immunology, Medical School of Hannover, Hannover, Germany</affiliation></name><typeOfResource>text</typeOfResource><genre>Original Article</genre><genre>Original Paper</genre><originInfo><publisher>Springer-Verlag, Berlin/Heidelberg</publisher><dateCreated encoding="w3cdtf">1993-11-23</dateCreated><dateCaptured encoding="w3cdtf">1994-05-11</dateCaptured><dateValid encoding="w3cdtf">2005-04-30</dateValid><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="eng">The role of platelet-associated immunoglobulins (PAIg) of four different immunoglobulin classes -IgM, IgG, IgA, and IgE- and their relation to platelet count and platelet kinetics was studied in 33 patients with idiopathic thrombocytopenic purpura (ITP). During the course of 1 year, repeated determinations of PAIg were made. The results indicate that PAIgG, PAIgM, and PAIgA are present in all ITP patients, and that autoantibodies of all three Ig classes show highly significant correlations to the platelet counts (p< 0.0001). Double logarithmic negative correlations have been found between PAIgG and platelet count (r=−0.71), PAIgM and platelet count (r=−0.84), and PAIgA and platelet count (r=−0.79). Statistical analyses using partial correlation and multiple regression methods showed that PAIgM is predominantly related to the platelet count, whereas PAIgG and PAIgA are only of secondary importance. Accordingly, a relation of PAIgM (and PAIgA) to increased liver destruction of platelets was found in kinetic studies using111indium-labeled platelets. Taken together, these results suggest a predominant role of PAIgM in the pathogenesis of ITP.</abstract><subject lang="eng"><genre>Key words</genre><topic>Purpura</topic><topic>Thrombocytopenic</topic><topic>Platelet-associated immunoglobulins</topic><topic>ITP</topic><topic>Autoimmunity</topic></subject><relatedItem type="series"><titleInfo type="abbreviated"><title>Ann Hematol</title></titleInfo><titleInfo><title>Annals of Hematology</title><partNumber>Year: 1994</partNumber><partNumber>Volume: 69</partNumber><partNumber>Number: 3</partNumber></titleInfo><genre>Archive Journal</genre><originInfo><dateIssued encoding="w3cdtf">1994-09-01</dateIssued><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><subject usage="primary"><topic>Medicine & Public Health</topic><topic>Hematology</topic><topic>Oncology</topic></subject><identifier type="issn">0939-5555</identifier><identifier type="issn">Electronic: 1432-0584</identifier><identifier type="matrixNumber">277</identifier><identifier type="local">IssueArticleCount: 13</identifier><recordInfo><recordOrigin>Springer-Verlag, 1994</recordOrigin></recordInfo></relatedItem><identifier type="doi">10.1007/BF01695692</identifier><identifier type="matrixNumber">Art5</identifier><identifier type="local">BF01695692</identifier><accessCondition type="use and reproduction">MetadataGrant: OpenAccess</accessCondition><accessCondition type="use and reproduction">AbstractGrant: OpenAccess</accessCondition><accessCondition type="restriction on access">BodyPDFGrant: Restricted</accessCondition><accessCondition type="restriction on access">BodyHTMLGrant: Restricted</accessCondition><accessCondition type="restriction on access">BibliographyGrant: Restricted</accessCondition><accessCondition type="restriction on access">ESMGrant: Restricted</accessCondition><part><extent unit="pages"><start>121</start><end>128</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1994</recordOrigin><recordIdentifier>277_1994_Article_BF01695692.pdf</recordIdentifier></recordInfo></mods></record>Pour manipuler ce document sous Unix (Dilib)
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